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KMID : 0604520090350040265
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Journal of the Society of Cosmetic Scientists of Korea
2009 Volume.35 No. 4 p.265 ~ p.270
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The Stimulatory Effects of Epimedium koreanum Nakai Extract on Melanogenesis
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Lee Eung-Ji
Bae Seong-Yun
Lee Yong-Hwa
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Abstract
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To develop a natural stimulating agent for hair melanogenesis, we investigated the stimulatory effects of Epimedium koreanum Nakai extract (EKNE) on melanogenesis. EKNE both increased melanin content in B16 melanoma cells up to about 104 % and intracellular tyrosinase activity up to about 95 % at a concentration of without cell cytotoxicity (below ). From the result of western blot, we could find that EKNE dose-dependently induce the expression of TRP-2. Also, EKNE increased melanogenesis up to about 25 % at a concentration of 5 % (w/v) in back hair of C3H/Hej mouse. These results suggest that EKNE has an effect to stimulate melanin formation through the induction of tyrosinase activity and TRP-2 expression which are involved in melanin synthesis in melanocyte. Therefore, we suggest that EKNE could be used as a useful melanogenesis stimulator for development of natural hair cosmetics.
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KEYWORD
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melanogenesis, Epimedium koreanum Nakai, hair, tyrosinase, TRP-2
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